Baltimore Sun

Baltimore Sun, Baltimore Ravens WR TJ Houshmandzadeh was stunned by his fall criticism that sealed his team’s 31-24 loss to the Pittsburgh Steelers on Saturday.

Ravens QB Joe Flacco targeted Houshmandzadeh on the fourth and-19 on the last-minute attempt to extend the team the game

But the ball rebounded Houshmandzadeh, who was guarded by Steelers CB William Gay.

“It’s unbelievable,” said Houshmandzadeh, through du”Baltimore Sun “I can not believe what happened. I bet every dollar I have that I do that. ”

Houshmandzadeh and has signed a EUR 40 million, five-year contract with the Seattle Seahawks in 2009. But Seattle cut before the start of the season – all in him because of over 6 million.

The Ravens signed him for a value and 855,000 contracts.

Houshmandzadeh had three catches for 38 yards in defeat against the Steelers.

Jeff Reed

Jeff Reed, In a season where the Steelers have been losing so many field goals in nine games as they had in the past three years the club has released the veteran kicker Jeff Reed.

Reed, who began the season as one of the 10 most accurate kickers in NFL history, cemented his fate on Sunday night by shanking a field goal from 26 yards against the Patriots.

It was Steelers kicker from the middle of the 2002 season, but will be replaced by former kicker for the Redskins and Cowboys Shaun Suisham.

He was drafted by the Steelers on Tuesday at Heinz Field. He missed seven of 22 attempts this season, including his four attempts from 40 – and 49-yard lines. He lost only eight combined in 62 attempts in 2008 and 2009 seasons.

Shaun Suisham

Shaun Suisham, On the night of Sunday, the Steelers kicker Jeff Reed said he expects to retire as a member of the Steelers.

If so, you better leave now.

Jay Glazer of FOX reports that the Steelers have cut Reed and signed Shaun Suisham. For the Pittsburgh Post-Gazette, kicker Suisham was only brought to Pittsburgh for a test Tuesday Gong Show. Worked out for coach Mike Tomlin and director of football operations Kevin Colbert at Heinz Field on Tuesday.

Suisham made 18 of 21 shots from the field of the Redskins in 2009 but was cut after missing a short field goal in overtime of a potential upset on the Saints. Suisham ended the season with the Cowboys, so two of three field goals in two regular season games and missing two of three in a playoff loss to the Vikings, including a 48-yard attempt that would have given the Cowboys a 3-0 lead.

As the team’s franchise player in 2010, Reed received a salary of 2.814 million guaranteed. If it is claimed on waivers, Reed’s new team will have to pay for it and 1.15 million over the balance of the season. If not claimed, Reed will pocket the balance of his salary for the Steelers – and he will be able to receive payment for his next team.

The Bengals currently do not have a kicker on the roster. But we can not imagine the Bengals pay no stimulation and 1.15 million for seven games.

Smoking Gun

Smoking Gun:Scientists have known for years for more than 1 million people die from lung cancer each year smokers. So when it came to seeking a genetic basis for lung cancer, there was much skepticism about the importance of this research, says molecular epidemiologist Neil Caporaso, Division of Cancer Epidemiology and Genetics at the National Cancer Institute (NCI).

But the evidence that lung cancer tends to run in families suggests there may be a hereditary component of the disease after all, and early studies identified genes that correlated with increased susceptibility to cancer. Such research, however, was limited by the technology of the time, which limits research to a single candidate gene and only a few hundred cases and controls per study. “Although we found some genes [with] the effects weak, this was thought to be unsatisfactory,” Caporaso recalls, “and really seemed to the new technology to help us.”

This new technology came in the form of genome-wide association (GWA) studies in which scientists can search through hundreds of thousands of genetic variants that may contribute to various diseases. When this technique was applied to the study of lung cancer, the results were profound: Three independent studies, this month’s Hot Papers, all identified a region on chromosome 15, which is strongly associated with risk of lung cancer. Specifically, carriers of certain mutations or polymorphisms in this region tended to have higher risk of lung cancer. Not surprisingly, the site contained three genes that encode three subunits of the nicotinic acetylcholine receptor.

“It makes sense that something beautifully that binds nicotine might have something to do with lung cancer,” says Caporaso, who did not participate in these studies. “What could be more logical?” A nicotinic acetylcholine receptors can trigger the behavior that causes lung cancer (smoking) and / or the cancer itself, interacting with certain carcinogens in snuff to stimulate tumor growth.

Since the publication of these documents, scientists have implicated two additional loci in susceptibility to lung cancer and a new consortium continues to hunt more. “The idea is that we do joint research on lung cancer,” says Hung Rayjean, a cancer epidemiologist at the Samuel Lunenfeld Research Institute in Toronto and first author of one of the three documents. “It will be a collaborative effort now.”
Cloudy picture

While it seems clear that the locus on chromosome 15 is associated with lung cancer, the same region also appears to be related to smoking, which exhibits a legacy that is even stronger than lung cancer, says Caporaso. As a result, it is unclear whether this region directly increases the risk of lung cancer, smoking increases the risk, which can lead to cancer, or if there was any interaction between genetics and behavior. “We knew that the effect could go both addiction and carcinogenesis pathways other,” says Hung, and data regarding whether this locus is associated with risk of lung cancer, directly or indirectly, were a little cloudy.

One study reported an association with lung cancer, regardless of smoking status, while another found an association only in smokers. The third suggests that the effect was mediated by nicotine addiction.

For now, “the issue remains unresolved,” says Caporaso. “No one is absolutely convinced [that the effect is independent of smoking]. You will need laboratory mechanistic studies, in addition to larger studies [] of non-smokers.”
Inhale Group

Shortly after the publication of work this month, two GWA studies follow two additional loci involved in susceptibility to lung cancer: a 51.2 in the chromosome and one in 6.2 genes on chromosome found in these regions are involved in DNA repair genes (a process that has been shown to play a role in lung cancer), and a component of telomerase, whose activity is believed to be vital for most forms of carcinogenesis.

Furthermore, some of the authors of these and of the three original studies joined with researchers from the NCI, including Caporaso, to carry out a meta-analysis of 11 studies GWA, for a total of more than 13,000 cases and nearly 20,000 controls 3 While the study was massive candidates who do not provide any other gene, it was to confirm the association of chromosome 15 rather than between the pulmonary tumor types of cancer, and reduced the place that contains the component of telomerase for only a lung cancer. Telomerase place also seems to be associated with risk of lung cancer in smokers, suggesting that the association is independent of smoking, the first molecular epidemiologist author Maria Teresa Landi of NCI said in an email.

In an effort to find new genetic factors, as well as to better understand those already identified, the International Lung Cancer Consortium (ILCCO) is collecting all available data GWAS, now totaling more than 40,000 cases. This huge data set can be used to study specific subgroups in more detail, says Caporaso, and non-smokers, women or ethnic groups. The consortium members meet once a year to discuss what studies can be done using the valuable resource, and recently submitted a joint grant application.

Genetic factors identified so far, “explained part of [the change in] the risk of lung cancer, but not everything,” says Hung. “We thought there might be some other genes associated with lung cancer.