Sangli Werewolf Sisters

Sangli Werewolf Sisters, Meet the incredible Sangli sisters, three siblings whose lives have been blighted by one of the rarest conditions in the world – werewolf sydrome.

Savita, 23, Monisha, 18, and 16-year-old Savitri are just like any other young women except their bodies have been covered from head to foot in thick hair.

Werewolf syndrome – or hypertricosis universalis – affects just one in a BILLION people but in an incredible quirk of fate all THREE sisters have the condition.

Hyperthrichosis is a genetic mutation where cells, that normally switch off hair growth in unusual areas, like the eyelids and forehead, are left switched on.

It means the girls have had abnormal hair growth on their bodies and even their faces, affecting their eyebrows, nose and giving them appearance of having a beard.

Every day is a battle for the siblings who are now just beginning to bring the condition under control using a special hair removal cream.

Compared to these pictures taken just last year the sisters, from southern India, have changed remarkably, and two of the sisters have managed to remove much of the hair growth from their faces.

Genetic Origins Parkinsons

Genetic Origins Parkinsons, Researchers have discovered how mutations in the parkin gene lead to the incurable Parkinson’s disease. The University of Buffalo findings reveal potential new drug targets for the disease as well as a screening platform for discovering new treatments that might mimic the protective functions of parkin. UB has applied for patent protection on the screening platform.

“This is the first time that human dopamine neurons have ever been generated from Parkinson’s disease patients with parkin mutations,” said Jian Feng, PhD, professor of physiology and biophysics in the UB School of Medicine and Biomedical Sciences and the study’s lead author.

Since in 2007, when Japanese researchers announced they had converted human cells to induced pluripotent stem cells (iPSCs) that could then be converted to nearly any cells in the body, mimicking embryonic stem cells, Feng and his UB colleagues saw their enormous potential. They have been working on it ever since.

“This new technology was a game-changer for Parkinson’s disease and for other neurological diseases,” said Feng.

“It finally allowed us to obtain the material we needed to study this disease.”

The current paper is the fruition of the UB team’s ability to “reverse engineer” human neurons from human skin cells taken from four subjects: two with a rare type of Parkinson’s disease in which the parkin mutation is the cause of their disease and two healthy subjects who served as controls.

“Once parkin is mutated, it can no longer precisely control the action of dopamine, which supports the neural computation required for our movement,” asserted Feng.

The UB team also found that parkin mutations prevent it from tightly controlling the production of monoamine oxidase (MAO), which catalyses dopamine oxidation.

“Normally, parkin makes sure that MAO, which can be toxic, is expressed at a very low level so that dopamine oxidation is under control,” Feng explained.

Werewolf Sisters Sangli

Werewolf Sisters Sangli, In an incredible quirk of fate three sisters are afflicted by one of the rarest condition in the world, affecting just one in a billion.

The Sangli sisters are suffering from a rare genetic disorder known as werewolf syndrome – where they are covered from head to toe in thick hair.

Savita, 23, Monisha, 18, and 16-year-old Savitri Sangli, who live in a small village near Pune, inherited the hypertrichosis universalis disorder from their father.

Hypertrichosis universalis is a genetic mutation, in which cells that normally switch off hair growth in unusual areas, like the eyelids and forehead, are left switched on.

The girls have abnormal hair growth on their faces, affecting their eyebrows, nose and giving them appearance of having a beard.

The sisters use hair removal cream to keep their condition under control on a temporary basis.

The cost of a laser surgery is around Rs 3,50,000, but the family is not wealthy enough to afford the specialised treatment.

The girl’s mother Anita Sambhaji Raut has six daughters in total with three of them having werewolf syndrome.

The condition was passed down by the girls’ father, who Anita was forced to marry at the age of 12.

Eldest daughter Savita says that she only gets a job for 10 to 15 days, and as soon as her hair starts showing through employers ask her to leave.

Anita and her daughters are desperate to fund laser surgery that will help to finally remove the curse of excess hair and allow the girls to lead normal lives.