Zinc And Larger Doses
August 4, 2011 by Post Team
Zinc And Larger Doses, There is no cure for the common cold but can be a way to shorten their suffering: A new study suggests that high doses of zinc lozenges in some formulations may shorten the duration of colds by more than 40 percent.
Dr. Harri Hemila of the University of Helsinki in Finland reviewed 13 placebo-controlled trials that examined the effect of zinc lozenges on common cold infections. Three of them found that zinc acetate in daily doses over 75 milligrams (mg) shortened the duration of colds, “42 percent on average.
Five trials with other salts of zinc acetate to daily doses above 75 mg reduced colds by an average of 20 percent, while five others with less than 75 mg per day had no effect.
“Much of the variation in the results of published studies may be explained by the daily dose of zinc is given zinc lozenges,” said Hemila, which funded the research itself. “When we focus on studies that have used large daily doses of zinc, there is strong evidence that zinc lozenges shorten the duration of colds.”
The study is published in the journal of respiratory medicine open.
Despite the popularity of zinc supplements, the controversy over its efficacy has been maintained since a highly publicized 1984 study first suggested a limiting effect of cold. Allow the tablet to dissolve rather than swallowing seemed to provide a therapeutic effect. Since then, more than a dozen studies have been conducted, but data on the effectiveness of the mineral has been uneven.
All studies reviewed by Hemila zinc lozenges compared with placebo. While his surprise that the strongest correlation was between daily doses of zinc and its effect on the duration of colds, “he said he and his colleagues still do not know why it seems to work.
“In the evidence-based medicine, we are primarily interested in whether there is an effect and how large, while the mechanism of the effect is a secondary issue,” he said.
No previous studies have shown that the use of zinc lozenges – even up to 150 mg per day – it could cause damage, apart from bad taste or constipation, Hemila said, and the most recent trial on zinc acetate showed no significant differences between the zinc and placebo groups in adverse conditions that effect despite the daily dose of zinc was 92 mg.
Dr. Lisa Winston, an epidemiologist at San Francisco General Hospital, praised the study as “a very clear summary of the data,” but noted that the trials reviewed Hemila involved small numbers of participants.
“It is an area of?? Controversy and question … I do not think the evidence is strong enough, nor do I think the author suggests that we can base clinical practice on it,” said Winston, also an associate professor in the University of California-San Francisco Department of Medicine. “I tell my patients who do not yet have a cure [for the common cold], and we do not know if the zinc works.”
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