Skeletal Dysplasia Medical
November 3, 2011 by staff
Skeletal Dysplasia Medical, A $ 6.6 million five-year grant from the National Institutes of Health will allow researchers at Baylor College of Medicine (www.bcm.edu) in collaboration with the University of California at Los Angeles (www.ucla.edu ) and the University of Washington in Seattle to study new forms recognized a brittle bone disease called osteogenesis imperfecta.
“There’s a whole new class of osteogenesis imperfecta (also known as a disease of brittle bone) that we have to study to understand from a human biochemistry and how to cause bone disease,” said Dr. Brendan Lee, a researcher main grant and professor of molecular and human genetics at BCM. Lee is also a Howard Hughes Medical Institute investigator (www.hhmi.org) and director of the skeletal dysplasia clinic at Texas Children’s Hospital (www.texaschildrens.org).
Osteogenesis imperfecta is the most common genetic disease of bone. Previously, investigators have linked to a single genetic defect associated with the ability to make a type of collagen, a connective tissue. However, new research – carried out for the first time in Lee’s laboratory and then followed by researchers, has identified six new genes associated with forms of the disease for which no cause is known before.
Part of this new study include understanding the genetic and biochemical aspects of this disorder. Another part is used high performance through new sequencing techniques BCM Human Genome Center sequencing to identify novel genes and test potential therapies.
Lee is also director of the bone Berdon Lawrence Rolanette and Disease Program of Texas, a collaborative research and clinical development of the Baylor College of Medicine and the University of Texas MD Anderson Cancer Center (www.mdanderson.org).
Lee will work with Drs. Don Cohn Deborah Krakow and at UCLA and Dr. David Eyre, University of Washington.
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