Human Serum Albumin Blood Protein
November 1, 2011 by staff
Human Serum Albumin Blood Protein, Scientists from a university in China, said Monday that rice can be used to albumin, a protein found in human blood is often used for treatment of burns, traumatic shock and liver diseases.
When extracted from the seeds of rice, the protein is “physically and chemically equivalent to blood-derived human serum albumin (HSA),” said the U.S. research, published Proceedings of the National Academy of Sciences.
The findings could lead to a breakthrough in the production of HSA, which usually comes from human blood donations.
The demand for blood protein is approximately 500 tons per year worldwide, and China has faced a shortage of concern in the past.
The method of rice was developed by scientists at Wuhan University in China and colleagues at the National Research Council of Canada and the Functional Genomics Center of the University of Albany in New York.
First, the genetic engineering of rice seeds to produce high levels of HSA. Then they developed a way to purify the protein from the seeds, the collection of about 2.75 grams of protein per kilogram (2.2 pounds) of rice.
When they tested the rice protein made in rats with liver cirrhosis, a common condition that often used the human equivalent, they found that the treatment produced similar results with HSA.
“Our results suggest that rice seed bioreactor produce recombinant HSA cost is safe and can help meet growing global demand for human serum albumin,” the study said.
Protein is often used in the manufacture of vaccines and drugs and is administered to patients with serious burn injuries, hemorrhagic shock and liver disease, researchers said.
In 2007, the shortage in China led to price increases and a brief increase in the number of albumin fraudulent medicines on the market.
Have also been raised about the potential for transmission of hepatitis and HIV, as the protein derived from human blood.
Large-scale planting of genetically modified rice fields that could produce enough seed for the mass production of the protein also raises concerns regarding the provision of environmental and food contamination, since rice is a staple of world food.
However, the study authors noted that the rice crop is largely self-pollination, which points to previous studies that showed “a very low frequency (0.04 to 0.80%) of pollen gene flow mediated between genetically modified (GM) and non-GM rice plants-adjacent. ”
More research is needed to evaluate the safety of the original rice protein in animals and humans before it can be considered for the market.
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