High Cholesterol Levels
September 13, 2011 by staff
Although the results do not directly demonstrate that high cholesterol causes Alzheimer’s disease or that the reduction would reduce the risk.
“We found that elevated cholesterol levels were significantly related brain plaques associated with Alzheimer’s disease,” said study author Kensuke Sasaki, MD, PhD, from Kyushu University in Fukuoka, Japan.
The researchers looked at the brains of 147 people (76 men, 71 women) who were residents of a Japanese city and live in 1988 when he underwent clinical examinations.
All participants died between 1998 and 2003.
About a third of them had been diagnosed with dementia during life.
Compared to people with low cholesterol levels, people with high cholesterol were more likely to have pieces of proteins known as plaques: 62 percent vs. 86 percent, respectively.
The study found no link between high cholesterol and tangles that develop in the brain with Alzheimer’s disease.
Along with high cholesterol increases the risk of Alzheimer’s disease, Sasaki previously that insulin resistance, a sign of diabetes may be another risk factor for brain plaques associated with Alzheimer’s disease.
“Our study clearly indicates that high cholesterol can contribute directly or indirectly to the plaques in the brain,” Sasaki said, “but not the treatment trials of cholesterol-lowering drugs in Alzheimer’s disease means there is no simple link between cholesterol reduction and prevention of Alzheimer’s disease. “
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